An Arousing Discovery on Catalepsy: Orexin Regulates Vestibular Motor Functions
نویسندگان
چکیده
منابع مشابه
An Arousing Discovery on Catalepsy: Orexin Regulates Vestibular Motor Functions
A study by Zhang et al. in this issue of Neuron reveals a novel mechanism of control of vestibular motor functions by the orexin (hypocretin) system in the perifornical/LH area through the lateral vestibular nucleus in the brainstem. This knowledge provides new insights into the understanding of brain circuitry that controls motor functions and diseases/conditions related to impairments in this...
متن کاملA Role for Orexin in Central Vestibular Motor Control
The absence of orexin results in narcolepsy-cataplexy. While the function of the central orexinergic system in sleep regulation has been well studied, the role of orexin in motor control is largely unknown. Here, we show that orexin-A acts via OX(1) and OX(2) receptors to directly depolarize neurons in the rat lateral vestibular nucleus (LVN), a subcortical motor center, and enhance their sensi...
متن کاملDiscovery Of An Orexin Receptor Positive Potentiator.
The orexin neurohormones control a variety of important physiological processes by signaling through two related G protein-coupled receptors, including appetite and feeding, wakefulness and energy homeostasis. Pharmacological manipulation of orexin signaling is an important goal. Here we describe the isolation of orexin receptor ligands from a library of microarray-displayed peptoids via a nove...
متن کاملOcular Motor Function in Patients with Bilateral Vestibular Weakness
Introduction: Patients with bilateral weakness (BW) have many difficulties in gaze stability that interfere with their normal function. The aim of this study was to evaluate ocular motor functions in patients with BW to better understand the problem of gaze instability in these patients. Materials and Methods: Patients were referred from the Otolaryngology Department for Vestibular Assessmen...
متن کاملAn Approach to Determining the Functions of Hypocretin (orexin)
Many papers on hypocretins/orexins begin with a list of the functions they regulate. Included in these lists are some of the following: sleep, food intake, water intake, gastric acid secretion, blood pressure, heart rate, movement, muscle tone, arousal, release of lutenizing hormone, corticosterone, insulin, growth hormone and prolactin. It is also reported that hypocretin/orexin coordinates mo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2011
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2011.02.017